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Correlation between secondary structure, cellular abundance and targeting efficiency of KSHV miRNAs
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The miRNAs are ranked according to their capacity to regulate the corresponding RLuc-based indicator constructs harboring two perfectly complementary target sequences into the 3′UTR of the Renilla luciferase gene. In gray are emphasized the miRNAs presenting optimal secondary hairpin structures and high levels of abundance in BCBL-1 cells.
aFrom Gottwein et al. (46).
