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. 2014 May 23;42(12):8024–8038. doi: 10.1093/nar/gku446

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Two types of Nrd1–RNA interaction described by NMR. (A) Comparison of Nrd1_307–491 binding to GUAA (red) and G7 (blue) RNA sequences. GUAA RNA is recognized mostly by residues within β-sheet surface, whereas G7 interaction is mediated by amino acids from the additional helix–loop bundle domain. (B) Structure of Nrd1_307–491 with highlighted regions that are responsible for AU-rich (red) and G-rich (blue) RNA binding. Overlapping region is shown in magenta. RNA-binding surface was colored based on the mutagenesis results. (C) A canonical RRM binds RNA via its β-sheet surface (red), exemplified here by the structure of sex-lethal RRM1 [PDB code: 1B7F; (55)].