Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun 26;42(12):7489–7527. doi: 10.1093/nar/gku447

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 14. — Mode of DNA binding by a TAL effector: DNA binding is mediated by a central region comprising a series of near-identical tandem repeats, usually 34 residues in length. The amino acid residues at positions 12 and 13 are hyper-variable (the ‘repeat variable di-residue’, or RVD). The side chain of residue 13 of each repeat determines the base recognized by that repeat in a simple but ambiguous 1:1 ‘recognition code’. The repeats precisely track the sense strand of the DNA, and so the order of the repeats determines the bp sequence recognized. The RVD (HD) is shown in red.