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An example of a REase catalytic site (MvaI, pdb: 2OAA). The nucleophilic water is oriented with tetrahedral geometry to ‘attack’ the phosphorus: one H-bond is to K87 and one H-bond to the 3′-phosphate oxygen, both of which might act as the general base. One lone pair orbital of the attacking water is to the metal ion, and one lone pair orbital to the phosphorus atom.
