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. 2014 May 28;42(12):7591–7610. doi: 10.1093/nar/gku451

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Gene expression associated with SPIB occupancy. (A) Gene expression values for OCI-LY3 (left panel) and LY10 (right panel) are shown as density plots, with the median and interquartile ranges (25th–75th) shown as a central line for all genes (Total) or genes associated with local factor occupancy (peak ±2kb of TSS) as shown on the y-axis, with log2 expression values on the x-axis. (B) Summary of SPIB knockdown results, representative western blot of SPIB knockdown in OCI-LY3 cells is shown on the left. The intersection of genes showing significant downregulation (adjusted p-value <0.05, >1.5-fold change) following 48 h SPIB knockdown with those also showing local SPIB occupancy (5 kb upstream/intragenic) is illustrated in the diagram on the right.