Table 2.
Examples of known gene targets of miR-143 and miR-145
| Gene | Biologic system of discovery | Gene expression in mesenchymal cells | Targeted by | Reference |
|---|---|---|---|---|
| ELK-1 | Fibroblast/VSMC | Yes | miR-143 | (30) |
| ERK-5 | Adipocytes | Yes | miR-145 | (31) |
| FLI | Colon cancer | Yes | miR-145 | (27) |
| IGFBP5 | Myofibroblasts | Yes | miR-143 | (17) |
| K-RAS | Epithelial malignancy | Yes | miR-143 | (32) |
| MUC1 | Epithelial malignancy | No | miR-145 | (29) |
| MYOCD | Fibroblast/VSMC | Yes | miR-145 | (30) |
| RREB-1 | Epithelial malignancy | Yes | miR-145 | (33) |
| VCAN | Muscle | Yes | miR-143 | (28) |