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. 2014 May 24;4:522–532. doi: 10.1016/j.fob.2014.05.003

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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Fig. 1 — Establishment of Smp30^Y/−Sod1^−/− male mice and Smp30^−/−Sod1^−/− female mice. (A) Cumulative survival rate in each experimental group of mice. (B) Appearance of Smp30^Y/−Sod1^−/− male mice and Smp30^−/−Sod1^−/− female mice at 14 days of age. (C) Body weight change in each experimental group (n = 10–11) between 7 and 14 days of age. The body weight of mice at 7 days was set at 100%. Open circles, Smp30^Y/+Sod1^+/+ or Smp30^+/+Sod1^+/+ mice; open triangles, Smp30^Y/+Sod1^+/− or Smp30^+/+Sod1^+/− mice; open squares, Smp30^Y/+Sod1^−/− or Smp30^+/+Sod1^−/− mice; filled circles, Smp30^Y/−Sod1^+/+ or Smp30^−/−Sod1^+/+ mice; filled triangles, Smp30^Y/−Sod1^+/− or Smp30^−/−Sod1^+/− mice; filled squares, Smp30^Y/−Sod1^−/− or Smp30^−/−Sod1^−/− mice. Values are given as means ± SEM. (D and E) Ascorbic acid (AA; filled columns) and dehydroascorbic acid (DHA; gray columns) concentration in plasma (D) and livers (E) from each experimental group of mice (n = 7–11) at 14 days. Values are given as means ± SEM (AA plus DHA).