Fig. 1.

Algorithm for decision making for introduction of a second anticholinergic. ¹If oxybutinin ER was not well tolerated, it was discontinued and changed for Tolterodine ER 4 mg. ²Suboptimal response: based on clinical and/or urodynamic study criteria. ³Introduction of the second anticholinergic medication. ⁴If tolterodine ER 4 mg was not well tolerated as a second anticholinergic medication, it was discontinued and changed for solifenacin 5 mg. ⁵If solifenacin was not well-tolerated, it was discontinued and alternative treatment was offered. ⊕ Addition of medication; : change of medication.