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. 2014 Jun 20;11(9):886–892. doi: 10.7150/ijms.9338

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Diagram of the integrated effects of pregnancy and chronic hypoxia on the interactions of PKC and K_Ca channels in modulating uterine arterial contractility. The diagram shows that under the normoxic condition, heightened basal BK channel activity in pregnant animals has a negative regulatory effect on PKC-induced contraction and myogenic tone of the uterine artery. Chronic hypoxia during gestation down-regulates basal BK channel activity and abrogates its inhibition of PKC-mediated myogenic response. In addition, chronic hypoxia induces an inhibitory effect of PKC on activated K_Ca channel-mediated relaxations of the uterine arteries in pregnant animals.