Table 3.

Association of sexual dysfunction composite outcome with mental health (MH) diagnostic category among 405,275 Iraq and Afghanistan male veterans in VA healthcare from October 7, 2001 to September 30, 2009, treating antidepressant and/or antipsychotic prescriptions as a time-varying covariate and after stepwise adjustment for potential confounding

	No MH Dx (N = 235,096)	MH Dx excluding PTSD (N = 59,956)		PTSD with and without other MH Dx (N = 110,223)
Sexual dysfunction composite outcome	RR/ARR (95% CI)	RR/ARR (95% CI)	P > z	RR/ARR (95% CI)	P > z
Unadjusted relative risk*	1.00 (ref.)	2.73 (2.62, 2.84)	<0.001	3.79 (3.65, 3.93)	<0.001
+ Sociodemographic and  military service†	1.00 (ref.)	3.11 (2.98, 3.24)	<0.001	4.65 (4.48, 4.83)	<0.001
+ Comorbidities‡	1.00 (ref.)	2.73 (2.62, 2.84)	<0.001	3.95 (3.80, 4.10)	<0.001
+ Opioid medications§	1.00 (ref.)	2.60 (2.49, 2.71)	<0.001	3.61 (3.48, 3.75)	<0.001

^*Unadjusted relative risk (RR) with 95% confidence interval (CI)

^†Adjusted relative risk (aRr). Multivariable analysis adjusted for sociodemographic and military service (MS) characteristics

^‡ARR. Multivariable analysis adjusted for sociodemographic and MS characteristics, comorbidities (HTN, dM, SCI, AUD, DUD, and smoking)

^§ARR. Multivariable analysis adjusted for sociodemographic and MS characteristics, comorbidities (HTN, DM, SCI, AUD, DUD, and smoking), and opioid medications

AUD = alcohol use disorder; DM = diabetes mellitus; DUD = drug use disorder; HTN = hypertension; PTSD = posttraumatic stress disorder; SCI = spinal cord injury