Table II.
Clinical features of the three patients at the time of diagnosis.
| Patient | |||
|---|---|---|---|
|
|
|||
| Parameter | A | B | C |
| Age/gender | 22/M | 34/F | 58/M |
| Fever | Yes | Yes | Yes |
| Splenomegaly | Yes | Yes | Yes |
| WBC (x109/l) | 0.70 | 2.10 | 2.20 |
| ANC (x109/l) | 0.50 | 0.80 | 1.20 |
| Hb (g/l) | 108 | 77 | 70 |
| PLT (x109/l) | 24 | 32 | 30 |
| ALT (U/l) | 382 | 104 | 642 |
| AST (U/l) | 794 | 143 | 514 |
| DBIL (μmol/l) | 208.42 | 8.10 | 108.70 |
| IBIL (μmol/l) | 32.60 | 6.20 | 29.30 |
| ALB (g/l) | 22.70 | 27.70 | 30.60 |
| LDH (U/l) | 2,532 | 885 | 702 |
| β2-MG (mg/l) | 7.75 | 6.34 | 4.20 |
| FIB (g/l) | 0.79 | 0.79 | 0.48 |
| TG (mmol/l) | 2.76 | 2.46 | - |
| SF (ng/ml) | 5700 | 3900 | 11816 |
| BM hemophagocytosis | Yes | Yes | Yes |
| EBV-DNA (U/ml) | 4.15×105 | - | - |
| Stage | IV | IV | IV |
| ECOG | 3 | 3 | 4 |
| IPI | H | HI | H |
M, male; F, female; WBC, white blood cell count; ANC, absolute neutrophil count; Hb, hemoglobin; PLT, platelets; ALT, alanine aminotransferase; AST, aspartate aminotransferase; DBIL, direct bilirubin; IBIL, indirect bilirubin; ALB, albumin; LDH, lactate dehydrogenase; β2-MG, β2-microglobulin; FIB, fibrinogen; TG, triglyceride; SF, serum ferritin; BM, bone marrow; EBV, Epstein Barr virus; ECOG, Eastern Cooperative Oncology Group scale; IPI, International Prognostic Index; H, high; HI, high intermediate.