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. 1999 Mar 15;103(6):807–815. doi: 10.1172/JCI5150

Figure 3.

Figure 3

Expression of CXCR3 and IP-10 in MS lesions. (a) Numerous CXCR3-immunoreactive cells are present in perivascular inflammatory infiltrates in an acute MS lesion in white matter surrounding a ventricle (vent). ×80. (b) CXCR3-immunoreactive cells in a perivascular infiltrate exhibit similar morphology and distribution to CD3-positive T cells (c). ×170. (d) Immunohistochemistry for IP-10 reveals staining of the cell bodies of reactive astrocytes (arrows). Intense staining is also seen in processes, consistent with astrocytic end-feet that extend to, and surround, a blood vessel. Scattered reactive astrocytes in the surrounding parenchyma also express IP-10 (arrowheads). ×300. CXCR3, type 3 CXC chemokine receptor.