Table II.
Association of the Axin2 SNP genotype (GG, GA or AA) and allele (G or A) with the incidence of prostate cancer in the patients (n=103) and controls (n=100).
| SNP | Genotype or allele | Controls, n (%) | Patients, n (%) | Crude OR (95% CI) | P-value | Adjusted ORa (95% CI) | P-value |
|---|---|---|---|---|---|---|---|
| rs2240308 | |||||||
| GG | 39 (39.0) | 61 (59.2) | 1.000 (Reference) | 1.000 (Reference) | |||
| GA | 52 (52.0) | 31 (30.1) | 0.381 (0.209–0.694) | 0.002 | 0.377 (0.206–0.688) | 0.001 | |
| AA | 9 (9.0) | 11 (10.7) | 0.781 (0.297–2.058) | 0.618 | 0.830 (0.309–2.232) | 0.712 | |
| non-GG | 61 (61.0) | 42 (40.8) | 0.440 (0.251–0.772) | 0.004 | 0.440 (0.250–0.774) | 0.004 | |
| G | 130 (65.0) | 153 (74.3) | 1.000 (Reference) | 1.000 (Reference) | |||
| A | 70 (35.0) | 53 (25.7) | 0.643 (0.420–0.990) | 0.042 | 0.583 (0.369–0.922) | 0.021 | |
a
Adjusted for age, smoking status and drinking status in a logistic regression model.
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.