Table IV.
Frequencies of Axin2 SNP genotypes (GG, GA or AA) and alleles (G or A) and the adjusted OR stratified by the aggressiveness of the cancer, for controls (n=100) versus patients (n=35) with localized PCa, and for controls (n=100) versus patients with advanced PCa (n=68).
| Genotype or allele | Controls, n (%) | Localized PCa, n (%) | Adjusted ORa (95% CI) | P-value | Controls, n (%) | Advanced PCa, n (%) | Adjusted ORa (95% CI) | P-value |
|---|---|---|---|---|---|---|---|---|
| GG | 39 (39.0) | 24 (68.6) | 1.00 (Reference) | 39 (39.0) | 37 (54.4) | 1.00 (Reference) | ||
| GA | 52 (52.0) | 9 (25.7) | 0.25 (0.10–0.61) | 0.002 | 52 (52.0) | 22 (32.4) | 0.45 (0.23–0.87) | 0.018 |
| AA | 9 (9.0) | 2 (5.7) | 0.38 (0.07–1.98) | 0.249 | 9 (9.0) | 9 (13.2) | 1.06 (0.37–3.02) | 0.921 |
| non-GG | 61 (61.0) | 11 (31.4) | 0.26 (0.11–0.62) | 0.002 | 61 (61.0) | 31 (45.6) | 0.53 (0.28–0.99) | 0.048 |
| G | 130 (65.0) | 57 (81.4) | 1.00 (Reference) | 130 (65.0) | 96 (70.6) | 1.00 (Reference) | ||
| A | 70 (35.0) | 13 (18.6) | 0.41 (0.21–0.81) | 0.010 | 70 (35.0) | 40 (29.4) | 0.67 (0.39–1.13) | 0.133 |
a
Adjusted for age, smoking status and drinking status in a logistic regression model.
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; PCa, prostate cancer.