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. 2014 Jun 7;14:412. doi: 10.1186/1471-2407-14-412

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Copyright © 2014 Abe et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Representative bands identified by Western blotting in 5637 and UM-UC-3 cells. Expression of RhoA (24 kDa), ROCK-I (160 kDa), ROCK-II (164 kDa), and beta-actin (42 kDa). Hela cells were used as the positive control. In both cancer cells, LPA plus GGOH induced upregulation of RhoA activity, ROCK-I and ROCK-II. While HA-1077 significantly decreased ROCK-I and ROCK-II expression, this inhibitory effect of HA-1077 was not blocked by addition of LPA plus GGOH. HA-1077 did not influence RhoA activity.