Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun 7;14:412. doi: 10.1186/1471-2407-14-412

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Abe et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

PMC Copyright notice

Inhibiting effect of HA-1077 on proliferation and RhoA activity and ROCK expression in 5637 cell using the 3-(4,5-dimethyl-2-thiazolyl)-2,5diphenyl-2H-tetrazolium (MTT) assay. The ratio of the cells treated with various doses (0.5–30 μM) of HA-1077 to control cells (HA-1077 0 μM) set as 1.0 were calculated. HA-1077 inhibited the growth of these cells in a dose-dependent manner (A). HA-1077 did not reduce the RhoA activity (B), but suppressed ROCK-I (C) and ROCK-II (D) in dose-dependent manner. The data show the 95% confidential interval.