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. 2014 Jun 7;14:412. doi: 10.1186/1471-2407-14-412

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Copyright © 2014 Abe et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Inhibiting effect of HA-1077 on proliferation and RhoA activity and ROCK expression in UM-UC-3 cell using the 3-(4,5-dimethyl-2-thiazolyl)-2,5diphenyl-2H-tetrazolium (MTT) assay. The ratio of the cells treated with various doses (0.5–30 μM) of HA-1077 to control cells (HA-1077 0 μM) set as 1.0 were calculated. HA-1077 inhibited the growth of UM-UC-3 cell in a dose-dependent manner (A). HA-1077 did not decrease the RhoA activity (B), but inhibited ROCK-I (C) and ROCK-II (D) in dose-dependent manner. The data show the 95% confidential interval.