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. 2014 Jun 7;14:412. doi: 10.1186/1471-2407-14-412

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Copyright © 2014 Abe et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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The effects of HA-1077 (0–30 μM) on migration in 5637 cell. The cancer cells were incubated in supplemented with HA-1077 with/without LPA and GGOH. (A) The percentage of migrated cells decreased in dose-dependent manner. LPA and GGOH blocked HA-1077 induced suppression of migration. (B-D) RhoA activity was not statistically different between with and without HA-1077, but ROCK-I and ROCK-II expression was significantly reduced in the cells on the underside of each filter. The data show the 95% confidential interval.