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. 1999 Mar 15;103(6):859–867. doi: 10.1172/JCI5734

Figure 3.

Figure 3

Effect of HLA-DQA1 and HLA-DQB1 peptides on IL-2 and IFN-γ production in the human MLR. Supernatants from human MLRs were taken daily for 7 days following incubation either alone or in the presence of HLA-DQA1 peptide (100–0.78 μg/ml) or HLA-DQB1 peptide (100–0.78μg/ml). Shown are IL-2 (a) and IFN-γ (b), assayed by ELISA on day 3. A biphasic effect of the HLA-DQA1 peptide on cytokine production was seen, similar to its effects on proliferation in the MLR: small doses were stimulatory, whereas larger doses were inhibitory. Results shown are representative of two separate experiments. IFN, interferon; IL, interleukin.