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Induction of apoptosis by HLA-DQA1 peptide, but not by HLA-DQB1 peptide. Lymphocytes primed in vivo to RT1.Duβ2 were restimulated with this peptide (a) alone or in the presence or absence of (b) HLA-DQA1 peptide (100 μg/ml) or (c) HLA-DQB1 peptide (100 μg/ml). Cells were examined at 1 h for evidence of apoptosis as determined by propidium iodide uptake using flow cytometry. Restimulation in the presence of HLA-DQA1 peptide resulted in significant apoptosis.
