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. Author manuscript; available in PMC: 2014 Jul 4.
Published in final edited form as: Brain Res. 2009 Mar 13;1260:7–14. doi: 10.1016/j.brainres.2008.12.078

Fig. 4.

Fig. 4

Dopamine D2 receptor activation is required for methanandamide (M-AEA) to attenuate cocaine (COC)-induced hyperthermia. Rats were injected with vehicle (VEH); raclopride (RAC) (5 mg/kg); M-AEA (5 mg/kg); or RAC (5 mg/kg) plus M-AEA (5 mg/kg). Twenty min later, rats were injected with COC (15 mg/kg) or saline (SAL) and body temperatures were recorded 30, 90, 90 120 and 180 min post-administration. Data are expressed as the mean±S.E.M. of the change in body temperature (ΔTb) from baseline (time 0). *P<0.05 compared to VEH+SAL; +P<0.05 compared to VEH+COC; and #P<0.05 compared to M-AEA+COC.