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. 2014 Jul 3;9(7):e100694. doi: 10.1371/journal.pone.0100694

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Phylogenetic tree layout was adapted from Yau and Hardie [40]. The deuterostome branch is labeled in green with dark green representing the phylum chordata. Tunicates and cephalochordates are subdivisions within this phylum with vertebrates representing the major group. Echinoderms (e.g., starfish, sea urchins, sea cucumbers) represent the second largest grouping of deuterostomes and are labeled in light green. The protostome branch is depicted below the dotted line in blue. Major phyla for which RGK protein orthologs/homologs were identified are presented in blue and the others in gray. Organisms with two letter abbreviation and common name (in parentheses) are depicted on the right.