Fig. 10.

Anatomical localisation of the AQP water shunt in OSCs, illustrated in an orthogonal-plane fluorescence optical sectioning (OPFOS)-based three-dimensional reconstruction of the helicotrema region in the adult guinea pig cochlea. The AQP water shunt (red outline) communicates along a distance of 804.31 ± 73.28 μm with the endolymph in the scala media (SM; green outline) and with the perilymph at the confluence of the scala vestibuli (SV; light blue outline) and the scala tympani (ST; dark blue outline) in the helicotrema. Scale bar, 500 μm