Table 1.
| CCV-related death? | ||||
|---|---|---|---|---|
| All patients | Yes | No | p-value | |
| Number of patients | 113,973 (100%) | 4,995 (4.4%) | 108,978 (95.6%) | --- |
| Traditional predictors | ||||
| Age | 63.4 ± 13.6 | 73.0 ± 10.8 | 62.9 ± 13.5 | < 0.001 |
| Male | 109,007 (95.6%) | 4,927 (98.6%) | 104,080 (95.5%) | < 0.001 |
| Systolic BP | 135.5 ± 16.3 | 138.5 ± 19.0 | 135.4 ± 16.1 | < 0.001 |
| Total/HDL chol. ratio | 4.4 ± 1.2 | 4.3 ± 1.2 | 4.4 ± 1.2 | < 0.001 |
| Diabetes diagnosis | 27,684 (24.3%) | 1,726 (34.6%) | 25,958 (23.8%) | < 0.001 |
| Medication data c | ||||
| Hypertension meds | 78,578 (68.9%) | 4,308 (86.2%) | 74,270 (68.2%) | < 0.001 |
| Lipids | 55,184 (48.4%) | 2,649 (53.0%) | 52,535 (48.2%) | < 0.001 |
| Diabetes meds | 24,940 (21.9%) | 1,573 (31.5%) | 23,367 (21.4%) | < 0.001 |
| Narcotics or opiates | 29,234 (25.6%) | 1,315 (26.3%) | 27,919 (25.6%) | 0.270 |
| Benzodiazepines | 14,375 (12.6%) | 678 (13.5%) | 13,700 (12.6%) | 0.052 |
| Levothyroxines | 7,989 (7.0%) | 516 (10.3%) | 7,473 (6.9%) | < 0.001 |
| Anticoagulants | 5,058 (4.4%) | 580 (11.6%) | 4,478 (4.1%) | < 0.001 |
| Labs, vitals, diagnoses & other | ||||
| Albumin | 3.9 ± 0.3 | 4.0 ± 0.3 | < 0.001 | |
| Blood urea nitrogen | 17.4 ± 6.5 | 21.6 ± 9.1 | 17.2 ± 6.3 | < 0.001 |
| LDL cholesterol | 112.1 ± 27.5 | 104.8 ± 26.3 | 112.5 ± 27.5 | < 0.001 |
| Serum creatinine | 1.1 (0.9–1.2) | 1.2 (1.0–1.4) | 1.1 (0.9–1.2) | < 0.001 |
| Pulse | 74.3 ± 12.3 | 74.1 ± 12.8 | 74.4 ± 12.3 | 0.180 |
| Pulse pressure | 60.5 ± 14.7 | 66.4 ± 16.8 | 60.3 ± 14.5 | < 0.001 |
| Baseline diagnoses: | ||||
| COPD | 27,523 (24.1%) | 1,455 (29.1%) | 26,068 (23.9%) | < 0.001 |
| Periodontitis | 4,749 (4.2%) | 93 (1.9%) | 4,656 (4.3%) | < 0.001 |
| Inflamm. arthritis | 1,655 (1.5%) | 76 (1.5%) | 1,579 (1.4%) | 0.720 |
| Sleep apnea | 1,174 (1.0%) | 18 (0.4%) | 1,156 (1.1%) | < 0.001 |
| Body mass index | 29.3 ± 5.6 | 28.2 ± 6.0 | 29.3 ± 5.6 | < 0.001 |
| Num. NEXIS visits | 3 (2–5) | 3 (2–5) | 3 (2–5) | 0.012 |
For categorical variables, n (%) is shown; for continuous variables, mean ± sd is shown except in case of a skewed distribution, for which median (IQR) is shown.
Among predictors with any missing values, missingness ranged between 2.8% (Systolic BP) and 45.7% (LDL cholesterol). Most patients (63.6%) had zero or one missing risk predictor value.
Lipids include: statins, fibrates, ezetimibe. Narcotics/opiates include: buprenorphine, codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, opium, oxycodone, pentazocine, propoxyphene, tramadol. Benzodiazepines include: alprazolam, chlordiazepoxide, clonazepam, clorazepate, diazepam, flurazepam, lorazepam, oxazepam, temazepam, triazolam. Anticoagulants include: dalteparin, enzoxaparin, fondaparinux, heparin, warfarin