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. Author manuscript; available in PMC: 2014 Jul 4.
Published in final edited form as: Curr Drug Targets. 2013 Sep;14(10):1192–1202. doi: 10.2174/13894501113149990192

Fig. (1).

Fig. (1)

The process of miRNA maturation. In the nucleus, RNA polymerase II (Pol II) transcribes pri-miRNA and is cleaved by the DROSHA/DGCR8 complex to form premiRNA. The pre-miRNA is then transported to the cytoplasm by exportin-5, where it is further processed by the RNase III endonuclease DICER to form mature single-stranded miRNA. Next, the strand enters the RISC and suppresses the target mRNA via either translational repression (partial complementarity) or target degradation (complete complementarity).