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. 2014 Jun 6;46(6):e99. doi: 10.1038/emm.2014.38

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Copyright © 2014 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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CD36-mediated signaling promotes atherosclerosis. The interaction between CD36 and oxidized LDL (oxLDL) provokes signaling cascades that mediate the uptake of oxLDL, cytokine production and macrophage trapping, thus promoting the atherosclerotic inflammatory process.