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An A/P Hybrid State tRNA
(A) Overview of the hybrid A/P (purple) and P/E tRNAs (green) visualized in the translating ribosome-Sec61 structure.
(B and C) Adoption of the hybrid A/P conformation (purple) relative to the canonical A-site tRNA (gray) requires a ∼13° rotation in the backbone of the tRNA just above the anticodon stem loop, as well as a 10° rotation in the acceptor/T-stem stack and a 9 Å displacement of the 3′ tail.
