Figure 4.

Interaction of Sec61 with the Ribosome

(A) Overview of the region of the ribosome surrounding the Sec61 complex, including the cytosolic loops 6/7 and 8/9. Sec61α is displayed in red, γ in tan, and β in light blue.

(B) Close-up of the cytosolic loops of Sec61 and the surrounding ribosomal proteins and RNA.

(C and D) Representative density for the cytosolic loops of Sec61α, regions of Sec61γ, and their corresponding helices.

(E) Hydrogen bonding interactions between residues H404 and R405 in loop 8/9 of Sec61α and ribosomal protein uL23 and the 28S rRNA.

(F) Visualization of a salt bridge between R20 in the N-terminal helix of Sec61γ and D148 in υΛ23.

(G) An arginine stack between residue R273 in loop 6/7 and R21 in eL39 is stabilized by interaction with the backbone of the 28S rRNA.

See also Figure S5.