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. 2014 Jun 19;157(7):1632–1643. doi: 10.1016/j.cell.2014.05.024

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© 2014 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).

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The Translating Ribosome-Sec61 Complex

(A) Cryo-EM density within the ribosomal exit tunnel for the nascent peptide (cyan), which spans from the A/P tRNA to Sec61. The location of ribosomal protein eL39, which lines the exit tunnel, is indicated.

(B) Ribosomal protein eL39 (bright blue) forms part of the exit tunnel (highlighted in cyan) and interacts with loop 6/7 of Sec61. Ribosomal protein uL23 (dark blue) contacts both eL39 and loop 8/9 of Sec61.

(C) Comparison of the Sec61 channel structures bound to idle or translating ribosome, showing movements in helices 1 and 10, which may be important for allowing translocation of the nascent polypeptide. Also see Figure S6.

(D) Rigid-body fitting of the idle Sec61 model (red) into the density for the translating Sec61-ribosome complex demonstrates that the plug is not visible in its canonical location. Displayed is an unsharpened map in which the disordered density for the detergent micelle has been removed using Chimera (Goddard et al., 2007).