Table 4. Flow-mediated dilation and endothelial dysfunction by elevated glucose and blood pressure stratified by gender.

	Elevated glucose	Elevated blood pressure	n	Age	FMD	FMDadjusted	ED, %
				(CI)	(CI)	(CI)	(FMD≤0%)
Women	No	No	1789	45.1	5.68a	5.48	13.7
				(44.4–45.7)	(5.47–5.87)	(5.44–5.51)
	No	Yes	690	57.1	4.57b	4.43	20.4
				(56.1–58.0)	(4.25–4.90)	(4.38–4.47)
	Yes	No	22	55.4	4.51c	4.61	27.3
				(49.7–61.9)	(2.59–6.32)	(4.34–4.87)
	Yes	Yes	27	64.5	2.73d	2.82	44.4
				(60.6–68.2)	(1.36–4.25)	(2.65–2.99)
Men	No	No	1136	46.1	4.49e	4.37	15.6
				(45.3–46.9)	(4.26–4.71)	(4.33–4.40)
	No	Yes	981	51.9	4.08f	3.98	19.0
				(51.0–52.8)	(3.82–4.33)	(3.94–4.01)
	Yes	No	38	51.4	4.66g	4.34	15.8
				(48.3–54.6)	(3.41–6.12)	(4.17–4.51)
	Yes	Yes	56	58.9	3.73h	3.79	23.2
				(55.9–62.2)	(2.73–4.67)	(3.66–3.92)

FMD:flow-mediated dilation; FMD_adjusted: predicted values of FMD adjusted for age; ED: endothelial dysfunction (FMD≤0%); elevated glucose: blood glucose ≥7.8 mmol/L; elevated blood pressure: systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥85 mmHg; n: numbers of participants; CI: 95% confidence interval. Annotations as letters on FMD groups to show differences between groups and p-values, with differences as follows with ANOVA;Difference with p<0.001; a from b, d, e, f and h, with p<0.05; a from c, d from b and e, f from b and e.pone.0101371.g004.tif