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. 2014 Jun 10;10(7):664–676. doi: 10.7150/ijbs.8232

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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ZAK is a target of URHC, and URHC down-regulates ZAK in SMMC7721 cells. (A) The ZAK gene is located near URHC on chromosome 2. (B) The relative mRNA levels of ZAK in HCC tissues (n=52) and matched normal tissues was determined using qRT-PCR. (C) A negative correlation between the relative mRNA levels of ZAK and URHC was observed in the above 52 HCC tissue samples (R²=0.1387, P=0.0066). (D) SMMC7721 cells were treated with URHC-siRNA, and the mRNA and protein levels of ZAK (E) were examined using qRT-PCR and western blot analyses, respectively. β-actin was used as a reference. The results show the means ± SD from 3 separate experiments. *, P < 0.05.