Table 3.

CFH single SNP association results in African Americans with putative type 2 diabetes-associated ESKD

				Model 1			Model 2
SNP	BP (hg19)	n, case/controlb	MAF, case/control	P-value	OR	95% CI	P-value	OR	95% CI
rs1061147	196654324	1284/691	0.42/0.46	0.015	0.85	0.74, 0.97	0.017	0.83	0.71, 0.97
rs1061170	196659237	1281/691	0.37/0.39	0.17	0.91	0.8, 1.04	0.042	0.85	0.72, 0.99
rs74443307	196670520	1288/722	0.017/0.012	0.20	1.44	0.82, 2.54	0.29	1.42	0.74, 2.71
rs35453854	196684855	1284/693	0.050/0.065	0.029	0.73	0.55, 0.97	0.37	0.85	0.60, 1.21
rs379489	196693451	1285/688	0.26/0.29	0.13	0.89	0.77, 1.04	0.049	0.84	0.7, 1.00
rs3753396	196695742	1284/690	0.050/0.057	0.60	0.93	0.69, 1.23	0.46	0.88	0.63, 1.23
rs142902005	196696005	1284/691	0.0016/0.00	—	—	—	—	—	—
rs515299	196706677	1284/690	0.20/0.22	0.22	0.91	0.77, 1.06	0.17	0.88	0.72, 1.06
rs1065489	196709774	1285/693	0.051/0.058	0.53	0.91	0.69, 1.21	0.35	0.85	0.61, 1.19
rs34362004	196711098	1284/694	0.013/0.017	0.28	0.74	0.43, 1.28	0.49	0.79	0.41, 1.53
rs35274867	196712596	1284/692	0.032/0.022	0.081	1.46	0.95, 2.24	0.011a	2.00	1.17, 3.40
rs34247141	196715063	1285/693	0.12/0.13	0.15	0.86	0.7, 1.06	0.63	0.94	0.73, 1.21
rs371680052	196716472	1286/691	0.0023/0.0014	0.55	1.63	0.33, 8.20	0.49	1.84	0.33, 10.17

MAF, minor allele frequency; OR, odds ratio; CI, confidence interval.

Model 1: Additive model adjusted for APOL1 and admixture.

Model 2: Model 1 + age and gender.

^aDominant model (LOF to additive P < 0.05).

^bSample sizes reflect those with complete clinical and genotypic data used in each analysis