Table 4. Within sib-pair interaction estimates for lipid traits by location, average daily fat intake and physical activity.
| SNP | Locus | Effect Allele | Trait | Interaction location−1 1 β ( 2 SE, 3 p) | Interaction location−2 4 β ( 2 SE, 3 p) | Interaction fat 5 β ( 2 SE, 3 p) | Interaction MET 6 β ( 2 SE, 3 p) |
| rs964184 | APOA1 | G | TG | 0.172 (0.044, 0.0001) | 0.147 (0.044, 0.001) | 0.107 (0.052, 0.040) | −0.058 (0.051, 0.248) |
| TC | 0.092 (0.043, 0.030) | 0.063 (0.043, 0.145) | 0.077 (0.051, 0.128) | 0.031 (0.049, 0.528) | |||
| HDL-C | 0.008 (0.042, 0.847) | 0.009 (0.043, 0.836) | −0.022 (0.050, 0.655) | 0.049 (0.048, 0.312) | |||
| LDL-C | 0.048 (0.043, 0.262) | 0.021 (0.043, 0.626) | 0.057 (0.051, 0.262) | 0.030 (0.049, 0.536) | |||
| rs3764261 | CETP | A | TG | 0.116 (0.036, 0.001) | 0.093 (0.037, 0.012) | 0.050 (0.043, 0.238) | −0.016 (0.042, 0.710) |
| TC | 0.141 (0.035, 0.0001) | 0.110 (0.035, 0.002) | 0.097 (0.041, 0.018) | 0.001 (0.040, 0.990) | |||
| HDL-C | 0.053 (0.034, 0.120) | 0.048 (0035, 0.169) | 0.023 (0.041, 0.569) | 0.033 (0.040, 0.403) | |||
| LDL-C | 0.096 (0.035, 0.006) | 0.070 (0.036, 0.051) | 0.085 (0.041, 0.042) | −0.010 (0.041, 0.804) | |||
| rs646776 | CELSR2-PSRC1-SORT1 | G | TG | 0.023 (0.040, 0.572) | 0.004 (0.041, 0.925) | −0.032 (0.049, 0.522) | −0.076 (0.045, 0.095) |
| TC | −0.011 (0.039, 0.339) | −0.037 (0.039, 0.339) | −0.092 (0.047, 0.051) | −0.081 (0.043, 0.062) | |||
| HDL-C | −0.025 (0.038, 0.509) | −0.026 (0.039, 0.507) | −0.060 (0.047, 0.201) | −0.002 (0.043, 0.961) | |||
| LDL-C | −0.007 (0.039, 0.853) | −0.033 (0.039, 0.403) | −0.061 (0.047, 0.200) | −0.063 (0.043, 0.145) | |||
| rs1412444 | LIPA | C | TG | 0.065 (0.030, 0.032) | 0.034 (0.031, 0.278) | −0.027 (0.036, 0.455) | −0.077 (0.033, 0.021) |
| TC | 0.115 (0.029, 0.0001) | 0.082 (0.030, 0.006) | 0.037 (0.034, 0.276) | −0.008 (0.032, 0.804) | |||
| HDL-C | 0.022 (0.028 (0.445) | 0.014 (0.029, 0.634) | −0.015 (0.034, 0.653) | 0.032 (0.032, 0.308) | |||
| LDL-C | 0.102 (0.029, 0.0005) | 0.076 (0.030, 0.011) | 0.056 (0.035, 0.105) | 0.000 (0.032, 0.999) | |||
| rs974819 | PDGFD | T | TG | 0.085 (0.035, 0.016) | 0.057 (0.036, 0.113) | −0.001 (0.042, 0.983) | −0.070 (0.039, 0.075) |
| TC | 0.070 (0.034, 0.039) | 0.037 (0.035, 0.283) | 0.029 (0.040, 0.472) | −0.019 (0.038, 0.625) | |||
| HDL-C | −0.039 (0.033, 0.240) | −0.047 (0.034, 0.166) | 0.007 (0.040, 0.866) | 0.005 (0.037, 0.896) | |||
| LDL-C | 0.055 (0.034, 0.109) | 0.028 (0.035, 0.427) | 0.034 (0.041, 0.410) | −0.017 (0.038, 0.648) | |||
| rs2954029 | TRIB1 | T | TG | 0.060 (0.035, 0.088) | 0.031 (0.036, 0.390) | 0.044 (0.040, 0.269) | −0.030 (0.040, 0.449) |
| TC | 0.132 (0.034, 0.0001) | 0.102 (0.034, 0.003) | 0.114 (0.038, 0.003) | 0.016 (0.038, 0.671) | |||
| HDL-C | 0.029 (0.033, 0.392) | 0.027 (0.034, 0.443) | 0.062 (0.038, 0.105) | 0.087 (0.038, 0.021) | |||
| LDL-C | 0.126 (0.034, 0.0001) | 0.103 (0.035, 0.003) | 0.111 (0.039, 0.004) | 0.012 (0.039, 0.751) |
β (Z score): within sib-pair interaction coefficient of regression for location (rural/urban) adjusted for age, sex and site (city).
SE: Standard Error.
Loci were considered to be significant at α = 0.05.
β (Z score): within sib-pair interaction coefficient of regression for location (rural/urban) adjusted for age, sex, site (city), fat intake and physical activity (total MET score).
β (Z score): within sib-pair interaction coefficient of regression for fat intake adjusted for age, sex, site (city), location (rural/urban) and total MET score.
β (Z score): within sib-pair interaction coefficient of regression for physical activity (total MET score) adjusted for age, sex, site (city), location (rural/urban) and fat intake. TG: trigylcerides; TC: total cholesterol; HDL-C: high density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol.