Table 1.
Prognostic scoring systems in alcoholic hepatitis
| Scoring system | Year | Formula | |||
| Maddrey DF (initial)[65] | 1978 | 4.63 × PT (s) + serum bilirubin (mg/dL) | |||
| Maddrey DF (modified)[66] | 1989 | 4.6 (patient’s PT - control PT) + serum bilirubin (mg/dL) | |||
| MELD (initial)[69] | 2000 | 10 × [0.957 × loge(creatinine mg/dL) + 0.378 × loge(bilirubin mg/dL) +1.120 x loge(INR) + 0.643 × cause of cirrhosis1] | |||
| MELD (modified)[70] | 2001 | 9.6 × loge(creatinine mg/dL) + 3.8 × loge(bilirubin mg/dL) +11.2 × loge(INR) + 6.4 | |||
| GAHS[68] | 2005 | Score given2 | 1 | 2 | 3 |
| Age (yr) | < 50 | ≥ 50 | |||
| WCC | 15 × 109/L | ≥ 15 × 109/L | |||
| Urea (mmol/L) | < 5 | ≥ 5 | |||
| INR | < 1.5 | 1.5-2 | > 2 | ||
| Bilirubin (μmol/L) | 125 | 125-250 | > 250 | ||
| Lille[72] | 2007 | 3.19 - 0.101 × (age in years) + 0.147 × (albumin day 0 in g/L) + 0.0165 × (bilirubin day 1 in μmol/L - bilirubin day 7 in μmol/L) - (0.206 × renal insufficiency3) - 0.0065 × (bilirubin day 0 in μmol/L) - 0.0096 × PT (s) | |||
| ABIC[73] | 2008 | (age × 0.1) + (serum bilirubin × 0.08) + (serum creatinine × 0.3) + (INR × 0.8) | |||
1
Cause of cirrhosis: 0 = alcohol or cholestasis; 1 = other etiology;
2
GAHS: a score is given for each variable, producing a combined score of between 5 and 12;
3
Renal insufficiency = 1 if creatinine ≥ 115 μmol/L; Renal insufficiency = 0 if creatinine < 115 μmol/L. DF: Discriminant Function; MELD: Model for End-Stage Liver Disease; GAHS: Glasgow alcoholic hepatitis score; ABIC: Age, bilirubin, INR and creatinine; PT: Prothrombin time; WCC: White cell count; INR: International normalized ratio.