Table 3.
Multivariate analysis of predictors of overall survival in gastric cancer
| HR (95%CI) | P value1 | |
| DNMT1 expression | ||
| Negative (n = 180) | Reference | 0.542 |
| Positive (n = 120) | 0.89 (0.60-1.31) | |
| DNMT3a expression | ||
| Negative (n = 106) | Reference | 0.025 |
| Positive (n = 194) | 1.60 (1.06-2.40) | |
| DNMT3b expression | ||
| HSCORE ≤ 200 (n = 154) | Reference | 0.620 |
| HSCORE > 200 (n = 146) | 1.17 (0.63-2.18) | |
| Lymph-vascular invasion | ||
| Absent (n = 138) | Reference | 0.130 |
| Present (n = 162) | 1.36 (0.91-2.03) | |
| TNM stage | ||
| I (n = 22) | Reference | |
| II (n = 51) | 1.78 (0.50-6.37) | 0.379 |
| III (n = 195) | 4.11 (1.30-13.05) | 0.016 |
| IV (n = 32) | 14.55 (4.38-48.31) | < 0.001 |
1
Cox proportional hazards model, adjusted for gender, age, smoking, drinking, lymph-vascular invasion, and DNMT expression. DNMT: DNA methyltransferase.