Fig. 11.

Effects of the DA uptake inhibitors RTI-113 and methylenedioxypyrovalerone (MDPV), the mixed-action uptake inhibitors cocaine and amitifadine, the NE uptake inhibitor nisoxetine, and the 5HT uptake inhibitor citalopram on ICSS in rats. Abscissae: frequency of brain stimulation in Hz (log scale). Ordinates: ICSS rate expressed as %MCR. Graphs show maximal facilitation produced in dose-effect studies conducted with each drug. Filled points show drug effects significantly different from vehicle as determined by two-way ANOVA and the Holm-Sidak post hoc test (P < 0.05). Data sets are published for RTI-113, nisoxetine and citalopram (Rosenberg et al., 2013), cocaine (Bauer et al., 2014), and MDPV (Bonano et al., 2014). Effects of amitifadine are unpublished but collected with identical procedures.