Fig. 13.

Effects of the nicotine, caffeine, diazepam, toluene vapor, MK801, and ketamine on ICSS in mice (diazepam, toluene) or rats (all other drugs). Abscissae: frequency of brain stimulation in Hz (log scale). Ordinates: ICSS rate expressed as %MCR. Graphs show maximal facilitation produced in dose-effect studies conducted with each drug. Filled points show drug effects significantly different from vehicle as determined by two-way ANOVA and the Holm-Sidak post hoc test (P < 0.05). Data sets are published for diazepam and toluene (Tracy et al., 2014) and for MK801 and ketamine (Hillhouse et al., 2014). Results with nicotine and caffeine are unpublished but collected with identical procedures.