Fig. 15.

Summary diagram for relating profiles of drug effects on ICSS to net abuse potential. Drugs can vary in their efficacies to produce abuse-related rate-increasing effects and abuse-limiting rate-decreasing effects, and both effects can be produced simultaneously. See Fig. 8 for examples. Net abuse potential can be conceptualized as an integration of these rate-increasing and rate-decreasing effects. In addition, the profile of rate-increasing and rate-decreasing effects varies over time after administration of a single drug dose, and may also change with repeated dosing.