TABLE 3.
Drug Pharmacologya | Doses | Route | Strain/Species | Sex | ICSS Procedureb | Drug Effectc | Dependent Measure | Reference | ||
---|---|---|---|---|---|---|---|---|---|---|
Drug Name | Selectivity | Structure | Parameter | |||||||
mg/kg | ||||||||||
Apomorphine | D1/D2 | 0.03–0.3 | s.c. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↑↓rate | Depoortere et al., 1996 |
Apomorphine | D1/D2 | 0.1 | s.c. | Wistar rat | Male | Hybrid | Amplitude | Depression | ↓rate | Strecker et al., 1982 |
SKF81297 | D1 | 0.125–1.5 | s.c. | Wistar rat | Male | Discrete trial | Amplitude | Depression | ↑CIT | Baldo et al., 1999 |
SKF81297 | D1 | 0.1–10 | i.p. | Swiss-Webster mouse | Male | Hybrid | Frequency | No effect | Malanga et al., 2008 | |
SKF81297 | D1 | 0.1–10 | i.p. | Swiss-Webster mouse | Female | Hybrid | Frequency | No effect | Malanga et al., 2008 | |
SKF82958 | D1 | 0.03–0.3 | i.p. | Swiss-Webster mouse | Male | Hybrid | Frequency | Facilitation | ↓M50 | Gilliss et al., 2002 |
Quinpirole | D2 | 0.03–1.0 | i.p. | Sprague-Dawley rat | Male | Hybrid | Frequency | Mixed | ↑↓rate | Depoortere et al., 1996 |
Quinpirole | D2 | 0.1–10 | i.p. | Swiss-Webster mouse | Male | Hybrid | Frequency | Mixed | ↑↓θ0 | Malanga et al., 2008 |
Quinpirole | D2 | 0.1–10 | i.p. | Swiss-Webster mouse | Female | Hybrid | Frequency | Mixed | ↑↓θ0 | Malanga et al., 2008 |
Quinpirole | D2 | 0.5–2.0 | i.p. | Long Evans rat | Male | Hybrid | Frequency | Mixed | ↓1/4 threshold | Nakajima and O’Regan, 1991 |
Rate, response rate; CIT, current-intensity threshold; θ0, theta-0 threshold; M50, EF50, or LOR, frequency maintaining 50% maximum rate; 1/4 threshold, frequency maintaining 25% maximum rate.
Dopamine receptor subtype selectivity
First column indicates structure of experimental session (see text for details). Second column indicates stimulation parameter under manipulation across trials.
Most prominent drug effect on ICSS.