TABLE 5.

Effects of other drugs on intracranial self-stimulation

Drug Pharmacologya		Doses	Route	Strain/Species	Sex	ICSS Procedureb		Drug Effectc	Dependent Measure	Reference
Drug Name	Mechanism					Structure	Parameter
		mg/kg
Nicotine	nAChR agonist	0.025–0.8	s.c.	Long Evans rat	Male	Hybrid	Frequency	Mixed	↓θ0	Bauco and Wise, 1994
Nicotine	nAChR agonist	0.06–1.0	s.c.	F-344 rat	Male	Discrete trial	Amplitude	Facilitation	↓CIT	Huston-Lyons and Kornetsky, 1992
Pentobarbital	GABAA + allosteric modulator	2.5–10	i.p.	Long Evans rat	Male	Hybrid	Frequency	Facilitation	↓M50	Bossert and Franklin, 2003
Diazepam	GABAA + allosteric modulator	0.5–4.0	i.p.	C57Bl6/J mouse	Male	Hybrid	Frequency	Facilitation	↓θ0	Straub et al., 2010
Toluene.	GABAA + allosteric modulator/NMDA ant	480–5000 ppm		C57Bl6/J mouse	Male	Hybrid	Frequency	Mixed	↓M50 ↑↓rate	Tracy et al., 2014
Phencyclidine	NMDA antagonist	0.5–5.0	i.p.	CDF rat	Male	Discrete trial	Amplitude	Facilitation	↓CIT	Kornetsky et al., 1979
Phencyclidine	NMDA antagonist	0.3–5.6	i.p.	Wistar rat	Male	Discrete trial	Amplitude	No effect		Bespalov et al., 1999
Phencyclidine	NMDA antagonist	2.5 and 5.0	i.p.	Long Evans rat	Male	Hybrid	Frequency	Mixed	↓θ0 ↑↓rate	Carlezon and Wise, 1993b
MK801	NMDA antagonist	0.01–0.3	i.p.	Lister rat	Male	Free operant		Mixed	↑↓rate	Herberg and Rose, 1989
MK801	NMDA antagonist	0.032–0.32	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Mixed	↑↓rate	Hillhouse et al., 2014
Ketamine	NMDA antagonist	0.3–100	i.p.	Lister rat	Male	Free operant		Mixed	↑↓rate	Herberg and Rose, 1989
Ketamine	NMDA antagonist	3.2–10	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Depression	↓rate	Hillhouse et al., 2014
THC	CB1/CB2 agonist	1.0	i.p.	Fischer 344 rat	Male	Hybrid	Frequency	No effect		Lepore et al., 1996
THC	CB1/CB2 agonist	1.0	i.p.	Lewis rat	Male	Hybrid	Frequency	Facilitation	↓θ0 ↓M50	Lepore et al., 1996
THC	CB1/CB2 agonist	1.0	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Facilitation	↓θ0	Lepore et al., 1996
THC	CB1/CB2 agonist	0.1 and 1.0	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Mixed	↑↓EF36.7	Katsidoni et al., 2013
THC	CB1/CB2 agonist	1.0–10	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Depression	↓rate	Kwilasz and Negus, 2012
Caffeine	adenosine antagonist	1.0–20	i.p.	Wistar rat	Male	Discrete trial	Amplitude	Mixed	↑↓CIT	Bespalov et al., 1999
Testosterone	anabolic steroid	50 μg		Sherman rat	Male	Free operant		Facilitation	↑rate	Caggiula and Hoebel, 1966
Tripelennamine	H1 antagonist	0.625–20	i.p.	CDF rat	Male	Discrete trial	Amplitude	Facilitation	↓CIT	Unterwald et al., 1984

Rate, response rate; CIT, current-intensity threshold; θ₀, theta-0 threshold; M₅₀ or EF₅₀, frequency maintaining 50% maximum rate; EF36.7, frequency maintaining 36.7% maximum rate.

^aMechanism of action or drug class.

^bFirst column indicates structure of experimental session (see text for details). Second column indicates stimulation parameter under manipulation across trials.

^cMost prominent drug effect on ICSS.