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. 2014 Jul 3;10(7):e1004188. doi: 10.1371/journal.ppat.1004188

Figure 4. Lung infiltrating cells and cytokine production in C57BL/6 and P2X7R−/− mice on day 28 p.i. with hypervirulent mycobacteria.

Figure 4

C57BL/6 and P2X7R−/− mice were infected i.t. with approx. 100 bacilli of H37Rv Mtb, Beijing 1471 Mtb and MP287/03 Mbv. Non-infected mice were used as controls. (A) The numbers of total, CD11b+, CD19+, CD4+ and CD8+ cells in the lungs are shown (means ± SD, n = 3). (B) IL-1β, IFNγ and IL-10 were quantified in the supernatants of lung cells after 48 h of culture (means ± SD, n = 3). Significant differences were observed for the indicated groups (*p<0.05, **p<0.01 and ***p<0.001). The data are representative of three separate experiments.