Figure 1A–1C shows the phenotype of the VCFS/DGS male child at age 2, 6, and 12 respectively. Note the periorbital fullness, narrow upslanting palpebral fissures, epicanthal folds, strabismus, thick lips with everted upper lip, and small everted ears. Figure 1D–1E shows the appearance of this child's mother at matching time intervals. The mother’s facial phenotype appears normal.