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Inhibition of EGFR and IGF-1R downstream signaling pathways by XGFR. LS174T colon carcinoma cells were incubated with XGFR, GA201, or R1507 parental antibodies at a concentration of 1000 nm in triplicates for 0.5, 6, 24, and 48 h. Levels of phosphorylated IGF-1R (A), RAF1 (B), AKT (C), and ERK1 (D) in total cell lysates were determined by the Luminex assay technology. Mean levels of relative phosphorylation in comparison with IgG-treated controls are depicted. Error bars, S.E.
