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Role of F2033.40 in CRF1R activation. A, GCGR-based homology model of CRF1R, used to depict the ligand-free basal state. Residues F2033.40, L3236.44, and Y3276.48 are shown, whose homologous amino acids in class A GPCRs play a key role in receptor activation. B, comparison of the amino acids at positions 3.40, 6.44, and 6.48 in the inactive (white) and active (orange) β2-AR and the inactive (gray) and active (brown) rhodopsin.
