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. 2014 Jul 1;20(1):41–53. doi: 10.1016/j.cmet.2014.03.031

Figure 1.

Figure 1

Effect of SC E2 on Energy Balance

(A–F) (A) Body weight change, (B) daily food intake, (C) in situ hybridization autoradiographic images, (D) Npy and Pomc mRNA levels in the ARC, (E) western blot autoradiographic images (left panel) and hypothalamic levels of proteins of AMPK pathway (right panel), and (F) hypothalamic malonyl-CoA levels of OVX rats and OVX rats SC treated with vehicle or E2.

(G and H) (G) Hypothalamic malonyl-CoA levels and (H) food intake of OVX rats SC treated with vehicle or E2 and ICV treated with vehicle or AICAR. Error bars represent SEM; n = 8–16 animals per experimental group. 3V: third ventricle; ∗, ∗∗ and ∗∗∗p < 0.05, 0.01, and 0.001 vs. OVX E2 SC or vehicle SC vehicle ICV; #p < 0.05 E2 SC vehicle ICV versus E2 SC AICAR ICV; ###p < 0.001 versus sham or E2 SC vehicle ICV versus E2 SC AICAR ICV.