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18FDG-PET standardized uptake value ratios (SUVRs) in brain regions relative to various reference tissues compared between wild-type (WT) and 5XFAD (AD) mice at 2, 5 and 13 months of age. At all ages, WT and AD mice could be distinguished using SUVRs. With increasing age, a greater number of changes in various SUVRs were observed. (*, p < 0.05; **, p < 0.01). AG: amygdala; BF: basal forebrain; BG: basal ganglia; HP: hippocampus; HT: hypothalamus; NC: neocortex; TL: thalamus.
