TABLE 4. Ethnic differences (odds ratios and 95% confidence interval) for severe white matter hyperintensity comparing African Caribbeans with Europeans.

Modela	Variable	OR (95% CI)	P
Model 1	Ethnicity	1.46 (1.02–2.08)	0.04
Model 2	Ethnicity	1.43 (1.00–2.04)	0.049
	History of stroke	1.66 (0.87–3.14)	0.1
Model 3	Ethnicity	1.29 (0.90–1.86)	0.2
	Antihypertensive therapy	1.81 (1.29–2.54)	0.001
Model 4	Ethnicity	1.34 (0.93–1.92)	0.1
	Clinic SBP (mmHg)	1.02 (1.01–1.03)	<0.0001
Model 5	Ethnicity	1.46 (1.02–2.10)	0.04
	TAC (ml/mmHg)	0.47 (0.28–0.79)	0.03
Model 6	Ethnicity	1.28 (0.89–1.85)	0.2
	HbA1c (%)	1.25 (1.04–1.49)	0.02
Model 7	Ethnicity	1.35 (0.94–1.94)	0.1
	Diabetes	1.46 (1.03–2.09)	0.04
Model 8	Ethnicity	1.49 (1.04–2.14)	0.03
	Urine ACR (mg/mmol)b	1.36 (1.16–1.59)	<0.0001
Model 9 – final multivariate	Ethnicity	1.12 (0.77–1.63)	0.6
	Clinic SBP (mmHg)	1.02 (1.01–1.03)	<0.0001
	HbA1c (%)	1.18 (0.98–1.42)	0.08
	Antihypertensive treatment	1.54 (1.09–2.19)	0.02
ABPM subgroup (n = 322)
Model 1	Ethnicity	2.08 (1.15–3.76)	0.02
Model 2 – final multivariate	Ethnicity	1.45 (0.74–2.83)	0.3
	Clinic SBP (mmHg)	1.00 (0.98–1.02)	0.7
	Night-time SBP (mmHg)	1.05 (1.02–1.07)	<0.0001
	HbA1c (%)	1.14 (0.82–1.60)	0.4
	Antihypertensive treatment	1.94 (1.04–3.62)	0.04

ABPM, ambulatory blood pressure monitoring; CI, confidence interval; OR, odds ratio.

^aAll models have age and sex forced into the model.

^bLog-transformed.