Table 3.
Overlap of the top 100 SNPs for the different GxE interaction methods in GLC GWAS
| “never” vs. “ever” smokers | “moderate” vs. “heavy” smokers | ||||||
|---|---|---|---|---|---|---|---|
| CC | CO | TWO | MUK-EB | MUR | EHB-GE | ||
| CC | 9 | 43 | 15 | 0 | 9 | ||
| CO | 30 | 64 | 60 | 16 | 100 | ||
| TWO | 59 | 66 | 56 | 11 | 64 | ||
| MUK-EB | 31 | 77 | 63 | 4 | 60 | ||
| MUR | 0 | 2 | 1 | 0 | 16 | ||
| EHB-GE | 30 | 100 | 66 | 77 | 2 | ||
CC = case-control; CO = case-only; TWO = intuitive two-step approach; MUK-EB = Mukherjee's empirical Bayes-type shrinkage estimator; MUR = Murcray's two step approach; EHB-GE = empirical hierarchical Bayes approach;