. 2014 May 29;180(2):223–232. doi: 10.1093/aje/kwu114

Table 3.

Odds of Colorectal Polyps Among Persons With GWAS-Identified Colorectal Cancer Susceptibility Loci in Polytomous Logistic Regression Analysis, by Polyp Subtype, Group Health Cooperative, Seattle, Washington, 1998–2007

Gene^a	Position	rs No.	Risk Allele^b	RAF in Controls^c (n = 781)	Cases With Colorectal Polyps									P for Comparison Between Case Groups
					Adenomas Only (n = 489)			Serrated Polyps Only (n = 401)			Adenomas + Serrated Polyps (n = 188)			P for Comparison Between Case Groups
					RAF	OR^d	95% CI	RAF	OR^d	95% CI	RAF	OR^d	95% CI	ADs vs. SPs	ADs vs. ADs + SPs	SPs vs. ADs + SPs
DUSP10	1q41	rs6691170	T	0.36	0.33	0.89	0.75, 1.05	0.34	0.89	0.74, 1.08	0.34	0.92	0.73, 1.18	0.96	0.76	0.80
MYNN	3q26.2	rs10936599	C	0.73	0.76	1.18	0.98, 1.42	0.74	0.99	0.81, 1.20	0.78	1.27	0.98, 1.67	0.11	0.57	0.08
EIF3H	8q23.3	rs16892766	C	0.08	0.08	1.01	0.75, 1.36	0.08	1.01	0.73, 1.40	0.09	1.14	0.77, 1.70	0.99	0.58	0.59
MYC	8q24	rs6983267	G	0.53	0.50	0.93	0.79, 1.09	0.49	0.91	0.76, 1.09	0.53	1.03	0.82, 1.29	0.85	0.39	0.33
	10p14^e	rs10795668	G	0.68	0.70	1.14	0.96, 1.36	0.69	1.09	0.90, 1.33	0.69	1.06	0.83, 1.36	0.69	0.59	0.84
	11q23.1^e	rs3802842	C	0.29	0.31	1.08	0.91, 1.28	0.26	0.86	0.71, 1.05	0.28	0.95	0.74, 1.21	0.03	0.32	0.50
DIP2B	12q13.13	rs11169552	C	0.71	0.73	1.12	0.94, 1.34	0.73	1.10	0.90, 1.34	0.73	1.11	0.86, 1.42	0.85	0.93	0.95
BMP4	14q22.2	rs4444235	C	0.49	0.45	0.87	0.74, 1.02	0.49	1.03	0.86, 1.23	0.47	0.94	0.75, 1.18	0.09	0.52	0.48
CRAC1/GREM1	15q13.3	rs4779584	T	0.23	0.24	1.06	0.88, 1.28	0.22	1.01	0.82, 1.39	0.24	1.07	0.82, 1.38	0.67	0.99	0.72
CDH1	16q22.1	rs9929218	G	0.71	0.75	1.24	1.04, 1.50	0.70	1.00	0.82, 1.21	0.74	1.23	0.95, 1.60	0.05	0.94	0.15
SMAD7	18q21.1	rs4939827	T	0.50	0.52	1.09	0.93, 1.29	0.49	0.93	0.76, 1.11	0.52	1.09	0.86, 1.37	0.10	0.97	0.22
RHPN2	19q13.1	rs10411210	C	0.89	0.90	1.14	0.87, 1.49	0.89	1.02	0.77, 1.36	0.89	1.01	0.70, 1.45	0.49	0.53	0.95
BMP2	20p12.3	rs961253	A	0.32	0.37	1.23	1.03, 1.46	0.38	1.24	1.03, 1.50	0.36	1.16	0.92, 1.48	0.90	0.67	0.61
Risk-allele score^f		NA	NA	NA	NA	1.07	1.01, 1.13	NA	1.00	0.94, 1.06	NA	1.07	0.99, 1.15	0.03	0.97	0.09

Abbreviations: AD, adenoma; CI, confidence interval; GWAS, genome-wide association studies; NA, not applicable; OR, odds ratio; RAF, risk allele frequency; rs, reference SNP; SNP, single-nucleotide polymorphism; SP, serrated polyp.

^a For gene abbreviations, see Table 1.

^b Allele associated with an increased risk of colorectal cancer in prior GWAS.

^c Reference category (OR = 1).

^d Odds per risk-allele increase; adjusted for study phase, age, race/ethnicity, and sex.

^e No known gene association with this locus.

^f Combined number of risk alleles across all SNPs in Table 3; possible values range from 0 to 26.