Skip to main content
. 2014 May 29;180(2):223–232. doi: 10.1093/aje/kwu114

Table 3.

Odds of Colorectal Polyps Among Persons With GWAS-Identified Colorectal Cancer Susceptibility Loci in Polytomous Logistic Regression Analysis, by Polyp Subtype, Group Health Cooperative, Seattle, Washington, 1998–2007

Genea Position rs No. Risk Alleleb RAF in Controlsc (n = 781) Cases With Colorectal Polyps
P for Comparison Between Case Groups
Adenomas Only (n = 489)
Serrated Polyps Only (n = 401)
Adenomas + Serrated Polyps (n = 188)
RAF ORd 95% CI RAF ORd 95% CI RAF ORd 95% CI ADs vs. SPs ADs vs. ADs + SPs SPs vs. ADs + SPs
DUSP10 1q41 rs6691170 T 0.36 0.33 0.89 0.75, 1.05 0.34 0.89 0.74, 1.08 0.34 0.92 0.73, 1.18 0.96 0.76 0.80
MYNN 3q26.2 rs10936599 C 0.73 0.76 1.18 0.98, 1.42 0.74 0.99 0.81, 1.20 0.78 1.27 0.98, 1.67 0.11 0.57 0.08
EIF3H 8q23.3 rs16892766 C 0.08 0.08 1.01 0.75, 1.36 0.08 1.01 0.73, 1.40 0.09 1.14 0.77, 1.70 0.99 0.58 0.59
MYC 8q24 rs6983267 G 0.53 0.50 0.93 0.79, 1.09 0.49 0.91 0.76, 1.09 0.53 1.03 0.82, 1.29 0.85 0.39 0.33
10p14e rs10795668 G 0.68 0.70 1.14 0.96, 1.36 0.69 1.09 0.90, 1.33 0.69 1.06 0.83, 1.36 0.69 0.59 0.84
11q23.1e rs3802842 C 0.29 0.31 1.08 0.91, 1.28 0.26 0.86 0.71, 1.05 0.28 0.95 0.74, 1.21 0.03 0.32 0.50
DIP2B 12q13.13 rs11169552 C 0.71 0.73 1.12 0.94, 1.34 0.73 1.10 0.90, 1.34 0.73 1.11 0.86, 1.42 0.85 0.93 0.95
BMP4 14q22.2 rs4444235 C 0.49 0.45 0.87 0.74, 1.02 0.49 1.03 0.86, 1.23 0.47 0.94 0.75, 1.18 0.09 0.52 0.48
CRAC1/GREM1 15q13.3 rs4779584 T 0.23 0.24 1.06 0.88, 1.28 0.22 1.01 0.82, 1.39 0.24 1.07 0.82, 1.38 0.67 0.99 0.72
CDH1 16q22.1 rs9929218 G 0.71 0.75 1.24 1.04, 1.50 0.70 1.00 0.82, 1.21 0.74 1.23 0.95, 1.60 0.05 0.94 0.15
SMAD7 18q21.1 rs4939827 T 0.50 0.52 1.09 0.93, 1.29 0.49 0.93 0.76, 1.11 0.52 1.09 0.86, 1.37 0.10 0.97 0.22
RHPN2 19q13.1 rs10411210 C 0.89 0.90 1.14 0.87, 1.49 0.89 1.02 0.77, 1.36 0.89 1.01 0.70, 1.45 0.49 0.53 0.95
BMP2 20p12.3 rs961253 A 0.32 0.37 1.23 1.03, 1.46 0.38 1.24 1.03, 1.50 0.36 1.16 0.92, 1.48 0.90 0.67 0.61
Risk-allele scoref NA NA NA NA 1.07 1.01, 1.13 NA 1.00 0.94, 1.06 NA 1.07 0.99, 1.15 0.03 0.97 0.09

Abbreviations: AD, adenoma; CI, confidence interval; GWAS, genome-wide association studies; NA, not applicable; OR, odds ratio; RAF, risk allele frequency; rs, reference SNP; SNP, single-nucleotide polymorphism; SP, serrated polyp.

a For gene abbreviations, see Table 1.

b Allele associated with an increased risk of colorectal cancer in prior GWAS.

c Reference category (OR = 1).

d Odds per risk-allele increase; adjusted for study phase, age, race/ethnicity, and sex.

e No known gene association with this locus.

f Combined number of risk alleles across all SNPs in Table 3; possible values range from 0 to 26.