. 2014 May 29;180(2):223–232. doi: 10.1093/aje/kwu114

Table 4.

Odds of Nonadvanced and Advanced Adenomas Associated With GWAS-Identified Colorectal Cancer Susceptibility Loci in Polytomous Logistic Regression Analysis, Group Health Cooperative, Seattle, Washington, 1998–2007^a

Gene^b	Position	rs No.	Risk Allele^c	RAF in Controls^d (n = 781)	Cases With Colorectal Polyps						P for Advanced Adenomas vs. Nonadvanced Adenomas
					Nonadvanced Adenomas (n = 296)			Advanced Adenomas (n = 181)
					RAF	OR^e	95% CI	RAF	OR^e	95% CI
DUSP10	1q41	rs6691170	T	0.36	0.33	0.91	0.74, 1.10	0.33	0.84	0.65, 1.07	0.59
MYNN	3q26.2	rs10936599	C	0.73	0.75	1.10	0.88, 1.36	0.78	1.32	1.01, 1.74	0.22
EIF3H	8q23.3	rs16892766	C	0.08	0.08	1.05	0.74, 1.48	0.12	1.48	1.02, 2.16	0.12
MYC	8q24	rs6983267	G	0.53	0.50	0.93	0.77, 1.12	0.53	1.04	0.83, 1.31	0.39
	10p14^f	rs10795668	G	0.68	0.68	1.03	0.84, 1.26	0.76	1.50	1.15, 1.96	0.01
	11q23.1^f	rs3802842	C	0.29	0.31	1.08	0.88, 1.32	0.31	1.12	0.88, 1.43	0.79
DIP2B	12q13.13	rs11169552	C	0.71	0.72	1.08	0.87, 1.34	0.74	1.19	0.91, 1.55	0.53
BMP4	14q22.2	rs4444235	C	0.49	0.46	0.90	0.74, 1.09	0.45	0.88	0.70, 1.11	0.88
CRAC1/GREM1	15q13.3	rs4779584	T	0.23	0.24	1.07	0.86, 1.33	0.26	1.22	0.93, 1.59	0.39
CDH1	16q22.1	rs9929218	G	0.71	0.73	1.13	0.91, 1.40	0.77	1.44	1.09, 1.89	0.13
SMAD7	18q21.1	rs4939827	T	0.50	0.51	1.04	0.86, 1.26	0.49	0.99	0.78, 1.25	0.70
RHPN2	19q13.1	rs10411210	C	0.89	0.90	1.10	0.81, 1.50	0.87	0.88	0.62, 1.25	0.28
BMP2	20p12.3	rs961253	A	0.32	0.37	1.27	1.04, 1.55	0.36	1.18	0.92, 1.51	0.60
Risk-allele score^g		NA	NA	NA	NA	1.04	0.98, 1.10	NA	1.13	1.05, 1.22	0.05

Abbreviations: CI, confidence interval; GWAS, genome-wide association studies; NA, not applicable; OR, odds ratio; RAF, risk allele frequency; rs, reference SNP; SNP, single-nucleotide polymorphism.

^a Analysis excludes 200 tubular adenoma cases that were missing data on polyp size.

^b For gene abbreviations, see Table 1.

^c Allele associated with an increased risk of colorectal cancer in prior GWAS.

^d Reference category (OR = 1).

^e Odds per risk-allele increase; adjusted for study phase, age, race/ethnicity, and sex.

^f No known gene association with this locus.

^g Combined number of risk alleles across all SNPs in Table 4; possible values range from 0 to 26.