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. 2014 May 29;180(2):223–232. doi: 10.1093/aje/kwu114

Table 4.

Odds of Nonadvanced and Advanced Adenomas Associated With GWAS-Identified Colorectal Cancer Susceptibility Loci in Polytomous Logistic Regression Analysis, Group Health Cooperative, Seattle, Washington, 1998–2007a

Geneb Position rs No. Risk Allelec RAF in Controlsd (n = 781) Cases With Colorectal Polyps
P for Advanced Adenomas vs. Nonadvanced Adenomas
Nonadvanced Adenomas (n = 296)
Advanced Adenomas (n = 181)
RAF ORe 95% CI RAF ORe 95% CI
DUSP10 1q41 rs6691170 T 0.36 0.33 0.91 0.74, 1.10 0.33 0.84 0.65, 1.07 0.59
MYNN 3q26.2 rs10936599 C 0.73 0.75 1.10 0.88, 1.36 0.78 1.32 1.01, 1.74 0.22
EIF3H 8q23.3 rs16892766 C 0.08 0.08 1.05 0.74, 1.48 0.12 1.48 1.02, 2.16 0.12
MYC 8q24 rs6983267 G 0.53 0.50 0.93 0.77, 1.12 0.53 1.04 0.83, 1.31 0.39
10p14f rs10795668 G 0.68 0.68 1.03 0.84, 1.26 0.76 1.50 1.15, 1.96 0.01
11q23.1f rs3802842 C 0.29 0.31 1.08 0.88, 1.32 0.31 1.12 0.88, 1.43 0.79
DIP2B 12q13.13 rs11169552 C 0.71 0.72 1.08 0.87, 1.34 0.74 1.19 0.91, 1.55 0.53
BMP4 14q22.2 rs4444235 C 0.49 0.46 0.90 0.74, 1.09 0.45 0.88 0.70, 1.11 0.88
CRAC1/GREM1 15q13.3 rs4779584 T 0.23 0.24 1.07 0.86, 1.33 0.26 1.22 0.93, 1.59 0.39
CDH1 16q22.1 rs9929218 G 0.71 0.73 1.13 0.91, 1.40 0.77 1.44 1.09, 1.89 0.13
SMAD7 18q21.1 rs4939827 T 0.50 0.51 1.04 0.86, 1.26 0.49 0.99 0.78, 1.25 0.70
RHPN2 19q13.1 rs10411210 C 0.89 0.90 1.10 0.81, 1.50 0.87 0.88 0.62, 1.25 0.28
BMP2 20p12.3 rs961253 A 0.32 0.37 1.27 1.04, 1.55 0.36 1.18 0.92, 1.51 0.60
Risk-allele scoreg NA NA NA NA 1.04 0.98, 1.10 NA 1.13 1.05, 1.22 0.05

Abbreviations: CI, confidence interval; GWAS, genome-wide association studies; NA, not applicable; OR, odds ratio; RAF, risk allele frequency; rs, reference SNP; SNP, single-nucleotide polymorphism.

a Analysis excludes 200 tubular adenoma cases that were missing data on polyp size.

b For gene abbreviations, see Table 1.

c Allele associated with an increased risk of colorectal cancer in prior GWAS.

d Reference category (OR = 1).

e Odds per risk-allele increase; adjusted for study phase, age, race/ethnicity, and sex.

f No known gene association with this locus.

g Combined number of risk alleles across all SNPs in Table 4; possible values range from 0 to 26.